Document Detail


The expression of the beta 1 integrin CD29 and the beta 2 integrin CD11b is decreased in peripheral blood lymphocytes from Graves' disease patients.
MedLine Citation:
PMID:  9758448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have prospectively examined the percentage of peripheral blood lymphocytes which expressed adhesion molecules in untreated Graves' disease patients. Eighteen patients with Graves' disease, twenty-four patients with Hashimoto's thyroiditis and thirty-two sex- and age-matched healthy control subjects were studied. The expression of the lymphocyte adhesion molecules beta-1 integrin CD29, beta-2 integrin CD11b and L-selectin Leu8 (CD62L) was analyzed by cytofluorometry. A decreased percentage of CD29+ and CD11b+ lymphocytes was observed in hyperthyroid patients in comparison with Hashimoto's thyroiditis patients and healthy controls. However, there was no difference in the percentage of CD62L+ lymphocytes in the three groups. Percentages of lymphocyte activation markers, hyperthyroid status, presence or absence of ophthalmopathy or serum levels of antithyroid antibodies were not related to the proportions of CD29+ or CD11b+ lymphocytes. Four Graves' patients required radical therapy but after the treatment, there was no modification in the percentages of CD29+ and CD11b+ lymphocytes compared with those determined at diagnosis. Our findings suggest that the decrease in beta-1 and beta-2 integrins could be a predisposing marker of development of Graves' disease.
Authors:
J A Girón; J Rojano; S Sasián; I Gavilán; M Aguilar; L Escobar
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  139     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Affiliation:
Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Facultad de Medicina, Cádiz, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD18 / biosynthesis*,  genetics
Antigens, CD29 / biosynthesis*,  genetics
Antithyroid Agents / therapeutic use
Biological Markers
Female
Graves Disease / drug therapy,  genetics,  metabolism*
Humans
Lymphocytes / metabolism*
Macrophage-1 Antigen / biosynthesis*,  genetics
Male
Methimazole / therapeutic use
Middle Aged
Prospective Studies
Thyroid Hormones / blood
Thyroiditis, Autoimmune / drug therapy,  genetics,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD18; 0/Antigens, CD29; 0/Antithyroid Agents; 0/Biological Markers; 0/Macrophage-1 Antigen; 0/Thyroid Hormones; 60-56-0/Methimazole

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