| The expression of apoptosis related genes in the first trimester human placenta using a short term in vitro model. | |
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MedLine Citation:
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PMID: 15711929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using in vitro model for studying the induction and inhibition of spontaneous apoptosis in human first trimester placental villi, mediated by the free radical scavenger SOD, we have examined the expression of bcl-xL, bax, Caspase-3 and PARP (Poly ADP-ribosyl). An increase in apoptosis was associated with activation of PARP and an increase and activation of Caspase-3. There was no significant change in bcl-x or bax. Therefore bcl-x and bax do not appear to have a significant role in apoptosis in the first trimester in vitro. Cleavage of Caspase-3 rather than transcriptional regulation appears to be the main determinant of Caspase-3 activity in first trimester placental villi. |
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Authors:
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A K Charles; S Hisheh; D Liu; R M Rao; B J Waddell; J E Dickinson; A J Rao; A M Dharmarajan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Apoptosis : an international journal on programmed cell death Volume: 10 ISSN: 1360-8185 ISO Abbreviation: Apoptosis Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-02-15 Completed Date: 2005-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Affiliation:
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Department of Pathology King Edward Memorial Hospital, University of Western Australia, Perth, Western Australia. adrian.charles@health.wa.gov.aau |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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genetics* Caspase 3 Caspases / metabolism Cell Culture Techniques* Chorionic Villi / physiology* Female Free Radical Scavengers / metabolism Humans Placenta* Pregnancy Pregnancy Trimester, First* RNA, Messenger / analysis Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/RNA, Messenger; EC 1.15.1.1/Superoxide Dismutase; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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