Document Detail

The expression of antioxidant enzymes in a mouse model of fetal alcohol syndrome.
MedLine Citation:
PMID:  22365038     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Superoxide dismutase, glutathione peroxidase, and catalase prevent cellular damage produced by free radicals. Our objective was to evaluate if prenatal alcohol exposure decreased the expression of antioxidant enzymes in the brain, liver, or placenta of fetal mice.
STUDY DESIGN: Timed, pregnant C57BL6/J mice were treated on gestational day 8 with intraperitoneal injection of alcohol (0.03 mL/g) or saline (control). Fetuses were harvested on gestational day 18. Fetal brain, liver, and placenta were analyzed for mRNA expression of superoxide dismutase, glutathione peroxidase, and catalase by real-time polymerase chain reaction, with 18S RNA used as reference.
RESULTS: Superoxide dismutase, glutathione peroxidase, and catalase expression was lower in fetal brains exposed to alcohol with no differences detected in the liver or placenta between the 2 groups.
CONCLUSION: Maternal alcohol consumption causes a decrease in superoxide dismutase, glutathione peroxidase, and catalase expression in the fetal brain. This may explain the long-term neurologic findings in fetal alcohol syndrome.
Nathan Drever; Huaizhi Yin; Talar Kechichian; Maged Costantine; Monica Longo; George R Saade; Egle Bytautiene
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Publication Detail:
Type:  Journal Article     Date:  2012-01-13
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  206     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358.e19-22     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
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MeSH Terms
Antioxidants / metabolism
Brain / enzymology
Catalase / biosynthesis*
Disease Models, Animal
Fetal Alcohol Syndrome / enzymology*
Glutathione Peroxidase / biosynthesis*
Liver / enzymology
Mice, Inbred C57BL
Placenta / enzymology
Superoxide Dismutase / biosynthesis*
Grant Support
Reg. No./Substance:
0/Antioxidants; EC; EC Peroxidase; EC Dismutase

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