| Is exposure to cocaine or cigarette smoke during pregnancy associated with infant visual abnormalities? | |
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MedLine Citation:
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PMID: 15287242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to assess the association between cocaine or cigarette smoke exposure in utero and visual outcome. A total of 153 healthy infants (89 males, 64 females; gestational age range 34 to 42 weeks) were prospectively enrolled in a masked, race-matched study. Quantitative analyses of urine and meconium were used to document exposure to cigarette smoke and cocaine. Infants with exposure to other illicit drugs, excepting marijuana, were excluded. At 6 weeks of age, grating acuity and visual system abnormalities (VSA; eyelid oedema, gaze abnormalities, and visual inattention) of 96 infants from the original study sample were assessed with the Teller acuity card procedure and a detailed neurological examination. Neither cocaine nor cigarette smoke exposure was associated with acuity or VSA. However, VSAs were associated with abnormal neurological examination, independent of drug exposure and other risk factors (odds ratio 7.9; 95% confidence interval 2.0 to 31.5;p=0.004). This unexpected finding could prove a helpful clinical marker for the infant at risk for neurological abnormalities. |
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Authors:
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Beatrice Latal Hajnal; Donna M Ferriero; J Colin Partridge; Delia A Dempsey; William V Good |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 46 ISSN: 0012-1622 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-03 Completed Date: 2004-08-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 520-5 Citation Subset: IM |
Affiliation:
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Growth and Development Centre, University Children's Hospital Zurich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Cocaine / adverse effects* Cocaine-Related Disorders / epidemiology Dopamine Uptake Inhibitors / adverse effects* Edema / chemically induced Eyelids Female Humans Infant Infant, Newborn Male Pregnancy Prenatal Exposure Delayed Effects* Prospective Studies Risk Factors Smoking / adverse effects*, epidemiology Vision Disorders / chemically induced*, epidemiology Visual Acuity |
| Grant Support | |
ID/Acronym/Agency:
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EY00384/EY/NEI NIH HHS; NS32553/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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