Document Detail

Is exposure to cocaine or cigarette smoke during pregnancy associated with infant visual abnormalities?
MedLine Citation:
PMID:  15287242     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess the association between cocaine or cigarette smoke exposure in utero and visual outcome. A total of 153 healthy infants (89 males, 64 females; gestational age range 34 to 42 weeks) were prospectively enrolled in a masked, race-matched study. Quantitative analyses of urine and meconium were used to document exposure to cigarette smoke and cocaine. Infants with exposure to other illicit drugs, excepting marijuana, were excluded. At 6 weeks of age, grating acuity and visual system abnormalities (VSA; eyelid oedema, gaze abnormalities, and visual inattention) of 96 infants from the original study sample were assessed with the Teller acuity card procedure and a detailed neurological examination. Neither cocaine nor cigarette smoke exposure was associated with acuity or VSA. However, VSAs were associated with abnormal neurological examination, independent of drug exposure and other risk factors (odds ratio 7.9; 95% confidence interval 2.0 to 31.5;p=0.004). This unexpected finding could prove a helpful clinical marker for the infant at risk for neurological abnormalities.
Beatrice Latal Hajnal; Donna M Ferriero; J Colin Partridge; Delia A Dempsey; William V Good
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  46     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-03     Completed Date:  2004-08-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  520-5     Citation Subset:  IM    
Growth and Development Centre, University Children's Hospital Zurich, Switzerland.
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MeSH Terms
Case-Control Studies
Cocaine / adverse effects*
Cocaine-Related Disorders / epidemiology
Dopamine Uptake Inhibitors / adverse effects*
Edema / chemically induced
Infant, Newborn
Prenatal Exposure Delayed Effects*
Prospective Studies
Risk Factors
Smoking / adverse effects*,  epidemiology
Vision Disorders / chemically induced*,  epidemiology
Visual Acuity
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine

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