| "For export only" medicines come back to Europe: a RP-LC method for the screening of six glucocorticoids in illegal and counterfeit anti-inflammatory and lightening creams. | |
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MedLine Citation:
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PMID: 20451342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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"For export only" anti-inflammatory and lightening creams are medicinal products sold in African countries for their skin whitening action. In the last years, Rapid Alerts from European Medicinal Regulatory Agencies evidenced the presence of a large number of illegal and counterfeit anti-inflammatory products advertised for their whitening action on black skin in the European market. These drugs, containing glucocorticoids, are illegally sold in Europe in unauthorized ethno-cosmetics-shops and mainly bought by immigrants. This paper reports a new RP-LC method for the rapid simultaneous screening of six different active ingredients in anti-inflammatory and whitening products (creams, ointment and suspension): betamethasone dipropionate, dexamethasone, fluocinonide, fluocinolone acetonide, clobetasol propionate, methyl-prednisolone acetate. The method was developed and validated in view of its possible application in quality control laboratories, mainly those appointed to the control of illegal/counterfeit medicinal products. The associated measurement uncertainty was calculated from validation data. The method was then applied to the analysis of whitening products obtained from the Italian illegal market. |
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Authors:
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M C Gaudiano; D Lucente; E Antoniella; P Bertocchi; N Muleri; L Manna; M Bartolomei; S Alimonti; L Valvo; A L Rodomonte |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-05-06 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 53 ISSN: 1873-264X ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 158-64 Citation Subset: IM |
Affiliation:
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Dipartimento del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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analysis* Chromatography, Reverse-Phase / methods* Dosage Forms Fraud Glucocorticoids / analysis* Ointments / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Dosage Forms; 0/Glucocorticoids; 0/Ointments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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