Document Detail

An exploratory ultrasound study of early gout.
MedLine Citation:
PMID:  22011529     Owner:  NLM     Status:  Publisher    
OBJECTIVES: We aimed to determine by ultrasonography (US) the prevalence of articular monosodium urate deposits in patients with gout who do not require urate lowering therapy (ULT) according to international recommendations. METHODS: In this prospective study, we enrolled patients with proven gout demonstrated by crystals in synovial fluid but who did not require ULT. Two trained ultrasonographers assessed 10 joints per patient (metatarsophalangeal [MTP] joints 1-2, knees, metacarpophalangeal [MCP] joints 2-3) to determine the prevalence of the double-contour (DC) sign and tophi in each site. RESULTS: We studied 150 joints from 15 patients (median age 56.9 years [interquartile range 31.7] years; 14 males). The median number of acute attacks per patient was 2.0 [0.7]. Interobserver agreement was good to excellent for all articular sites. The prevalence of the DC sign in the knees and MTP joints was 46.7% and 40% respectively, whereas that of tophi was 26.7% for both sites. No urate deposits were found in MCP joints. The DC sign and tophi were found in at least one articular site in 60% and 46.7% of patients, respectively. All patients with urate levels > 600 μM (10 mg/dl) had a DC sign in at least 1 assessed joint. Urate levels were positively correlated with presence of the DC sign in knees (p=0.005) and MTP joints (p=0.03) but not presence of tophi. CONCLUSIONS: In this study, ultrasonography allowed for detecting articular urate deposits in 60% of gouty patients not requiring ULT by international recommendations.
Sébastien Ottaviani; Anne Allard; Thomas Bardin; Pascal Richette
Related Documents :
22664899 - Preoperative assessment of taste function in patients with middle ear disease.
21784619 - Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis.
21943939 - Arrhythmic manifestations in patients with congenital left ventricular aneurysms and di...
21646739 - Elevated cardiac troponin t predicts adverse outcomes in hypertensive patients.
22046579 - Capsaicin-sensitive afferentation represents an indifferent defensive pathway from erad...
22471499 - Altered serum levels of elements in acute leukemia cases in turkey.
7871949 - Hematuria in sickle cell anemia--not always benign: evidence for excess frequency of si...
3781179 - Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency.
9326189 - Analysis of p53 gene deletions in patients with non-hodgkin's lymphoma by dual-colour f...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  -     ISSN:  0392-856X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Université Paris 7, UFR médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Lariboisière, Fédération de Rhumatologie, 75475 Paris Cedex 10, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  When balanced for precursor fatty acid supply echium oil is not superior to linseed oil in enriching...
Next Document:  Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated...