Document Detail

An exploratory study of physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia.
MedLine Citation:
PMID:  16371025     Owner:  NLM     Status:  MEDLINE    
This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants (14 SCA; 14 age- and ethnic-similar controls) were assessed longitudinally with the Bayley Infant Neurodevelopmental Screener (BINS) at 3, 9 and 12 months. Transcranial Doppler (TCD) and pulse oximetry (SpO2) measures were recorded longitudinally in SCA infants, and a subgroup of controls. Haemoglobin values were obtained from SCA infants. At each age, SCA infants obtained BINS scores indicative of greater risk of neurodevelopmental delay compared with controls. The number of moderate-high BINS risk scores increased significantly between 3 and 9 months. At 9 months BINS raw scores correlated negatively with TCD velocity and positively with haemoglobin. This exploratory study suggests that SCA infants may be at greater risk of neurodevelopmental delay than previously considered, and may provide the impetus for further research into the very early precursors of cognitive impairment.
Alexandra M Hogan; Fenella J Kirkham; Mara Prengler; Paul Telfer; Roderick Lane; Faraneh Vargha-Khadem; Michelle Haan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  132     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-22     Completed Date:  2006-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Institute of Child Health, University College London, London, UK.
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MeSH Terms
Aging / blood
Anemia, Sickle Cell / blood,  psychology*
Birth Weight
Child Development*
Cognition Disorders / diagnosis,  etiology
Developmental Disabilities / diagnosis,  etiology*
Epidemiologic Methods
Hemoglobins / metabolism
Infant, Newborn
Neuropsychological Tests
Oxygen / blood
Ultrasonography, Doppler, Transcranial
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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