| An exploratory study of physiological correlates of neurodevelopmental delay in infants with sickle cell anaemia. | |
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MedLine Citation:
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PMID: 16371025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to investigate whether infants with sickle cell anaemia (SCA) are at risk of neurodevelopmental delay, and whether any delay is associated with SCA pathology. Twenty-eight infants (14 SCA; 14 age- and ethnic-similar controls) were assessed longitudinally with the Bayley Infant Neurodevelopmental Screener (BINS) at 3, 9 and 12 months. Transcranial Doppler (TCD) and pulse oximetry (SpO2) measures were recorded longitudinally in SCA infants, and a subgroup of controls. Haemoglobin values were obtained from SCA infants. At each age, SCA infants obtained BINS scores indicative of greater risk of neurodevelopmental delay compared with controls. The number of moderate-high BINS risk scores increased significantly between 3 and 9 months. At 9 months BINS raw scores correlated negatively with TCD velocity and positively with haemoglobin. This exploratory study suggests that SCA infants may be at greater risk of neurodevelopmental delay than previously considered, and may provide the impetus for further research into the very early precursors of cognitive impairment. |
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Authors:
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Alexandra M Hogan; Fenella J Kirkham; Mara Prengler; Paul Telfer; Roderick Lane; Faraneh Vargha-Khadem; Michelle Haan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of haematology Volume: 132 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-22 Completed Date: 2006-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 99-107 Citation Subset: IM |
Affiliation:
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Institute of Child Health, University College London, London, UK. a.hogan@soton.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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blood Anemia, Sickle Cell / blood, psychology* Birth Weight Child Development* Cognition Disorders / diagnosis, etiology Developmental Disabilities / diagnosis, etiology* Epidemiologic Methods Female Hemoglobins / metabolism Humans Infant, Newborn Male Neuropsychological Tests Oximetry Oxygen / blood Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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