| An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer. | |
| | |
MedLine Citation:
|
PMID: 19036529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: Hypoxia in patients with head-and-neck cancer (HNC) is well established and known to cause radiation resistance and treatment failure in the management of HNC. This study examines the role of parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perfusion computed tomography (CT) as surrogate markers of intratumoral hypoxia, defined by using the exogenous marker of hypoxia pimonidazole and the endogenous marker carbonic anhydrase 9 (CA9). METHODS AND MATERIALS: Patients with HNC underwent preoperative DCE-MRI, perfusion CT, and pimonidazole infusion. Imaging parameters were correlated with pimonidazole and CA9 staining. The strength of correlations was tested by using a two-tailed Spearman's rank correlation coefficient. RESULTS: Twenty-three regions of interest were analyzed from the 7 patients who completed the DCE-MRI studies. A number of statistically significant correlations were seen between DCE-MRI parameters (volume transfer between blood plasma and extracellular extravascular space [EES], volume of EES, rate constant between EES and blood plasma, time at arrival of contrast inflow, time to peak, average gradient, and time to onset) and areas with a pimonidazole score of 4. In the case of CA9 staining, only a weak correlation was shown with wash-in rate. There were no significant correlations between perfusion CT parameters and pimonidazole staining or CA9 expression. CONCLUSION: Intratumoral hypoxia in patients with HNC may be predicted by using DCE-MRI; however, perfusion CT requires further investigation. |
| | |
Authors:
|
Kate Newbold; Isabel Castellano; Elizabeth Charles-Edwards; Dorothy Mears; Aslam Sohaib; Martin Leach; Peter Rhys-Evans; Peter Clarke; Cyril Fisher; Kevin Harrington; Christopher Nutting |
Related Documents
:
|
17296999 - Dynamic 3d-ct angiography. 6298289 - Dynamic incremental computed tomography in evaluation of the pulmonary hila. 22145089 - Sternberg's canal as a cause of encephalocele within the lateral recess of the sphenoid... 12065119 - Application of dynamic mri to differentiating odontogenic myxomas from ameloblastomas. 17591639 - Zoonotic cutaneous leishmaniasis in central tunisia: spatio temporal dynamics. 9817089 - Fast dynamic contrast-enhanced colour-coded mri in uterine cervix carcinoma: useful for... 2995779 - Signal strength on a 0.15-t magnetic resonance imager. 19137039 - Cascaded adaptive-mask algorithm for twin-image removal and its application to digital ... 9766309 - Depth electrode implantation in the length axis of the hippocampus for the presurgical ... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-25 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 74 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-13 Completed Date: 2009-04-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
|
The Royal Marsden Hospital, Sutton, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carbonic Anhydrases / analysis, metabolism Cell Hypoxia* Contrast Media / pharmacokinetics Female Head and Neck Neoplasms / blood supply, metabolism*, surgery Humans Iohexol / pharmacokinetics Magnetic Resonance Imaging / methods* Male Middle Aged Nitroimidazoles / diagnostic use, pharmacokinetics Radiation Tolerance Radiation-Sensitizing Agents / diagnostic use, pharmacokinetics Statistics, Nonparametric Tomography, Spiral Computed / methods* Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Nitroimidazoles; 0/Radiation-Sensitizing Agents; 0/Tumor Markers, Biological; 66108-95-0/Iohexol; 70132-51-3/pimonidazole; EC 4.2.1.1/Carbonic Anhydrases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of smoking and alcohol drinking behaviors on treatment outcomes of patients with squamous ...
Next Document: Evaluation of dosimetric parameters and disease response after 125 iodine transperineal brachytherap...