Document Detail

An exploratory study of the associations between maternal iron status in pregnancy and childhood wheeze and atopy.
MedLine Citation:
PMID:  25342229     Owner:  NLM     Status:  Publisher    
Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In the present study, the associations between maternal Fe status during pregnancy and childhood outcomes in the first 10 years of life were investigated in a subgroup of 157 mother-child pairs from a birth cohort with complete maternal, fetal ultrasound, blood and child follow-up data. Maternal Fe intake was assessed using FFQ at 32 weeks of gestation and Hb concentrations and serum Fe status (ferritin, soluble transferrin receptor and TfR-F (transferrin receptor:ferritin) index) were measured at 11 weeks of gestation and at delivery. Maternal Fe intake, Hb concentrations and serum Fe status were found to be not associated with fetal or birth measurements. Unit increases in first-trimester maternal serum TfR concentrations (OR 1·44, 95 % CI 1·05, 1·99) and TfR-F index (OR 1·42, 95 % CI 1·10, 1·82) (i.e. decreasing Fe status) were found to be associated with an increased risk of wheeze, while unit increases in serum ferritin concentrations (i.e. increasing Fe status) were found to be associated with increases in standardised mean peak expiratory flow (PEF) (β 0·25, 95 % CI 0·09, 0·42) and forced expiratory volume in the first second (FEV1) (β 0·20, 95 % CI 0·08, 0·32) up to 10 years of age. Increasing maternal serum TfR-F index at delivery was found to be associated with an increased risk of atopic sensitisation (OR 1·35, 95 % CI 1·02, 1·79). The results of the present study suggest that reduced maternal Fe status during pregnancy is adversely associated with childhood wheeze, lung function and atopic sensitisation, justifying further studies on maternal Fe status and childhood asthma and atopic disease.
Bright I Nwaru; Helen Hayes; Lorraine Gambling; Leone C A Craig; Keith Allan; Nanda Prabhu; Steven W Turner; Geraldine McNeill; Maijaliisa Erkkola; Anthony Seaton; Harry J McArdle; Graham Devereux
Related Documents :
16310039 - The granzyme b inhibitor, pi-9, is differentially expressed during placental developmen...
17237549 - Feto-maternal cell trafficking: a transfer of pregnancy associated progenitor cells.
2915349 - Immunohistochemical investigation of secretory component and immunoglobulin a in the ge...
23637079 - The fetal frontomaxillary facial angle in normal and trisomy 21 ultrasounds at 11-13(+6...
25437119 - Maternal salivary cortisol levels during pregnancy are positively associated with overw...
25165809 - Effects of maternal smoking on the placental expression of genes related to angiogenesi...
10443579 - Physiological modulation of gaba(a) receptor plasticity by progesterone metabolites.
23612929 - Signal quality of non-invasive fetal electrocardiogram in vaginal breech delivery: a ca...
8501739 - Suboptimal progesterone production in pathologic pregnancies.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-24
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-24     Completed Date:  -     Revised Date:  2014-10-25    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-10     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Graphenes in the absence of metals as carbocatalysts for selective acetylene hydrogenation and alken...
Next Document:  Discovery and Comparative Analysis of a Novel Satellite, EC137, in Horses and Other Equids.