Document Detail


An exploratory prospective study of marijuana use and mortality following acute myocardial infarction.
MedLine Citation:
PMID:  18294478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relationship of marijuana use with coronary heart disease, including prognosis among patients with coronary heart disease, is uncertain. METHODS: We conducted an inception cohort study of 1913 adults hospitalized with myocardial infarction at 45 US hospitals between 1989 and 1994, with a median follow-up of 3.8 years. We ascertained total mortality according to self-reported marijuana use in the preceding year. RESULTS: A total of 52 patients reported marijuana use during the prior year, and 317 patients died during follow-up. Compared with nonuse, marijuana use less than weekly was associated with a hazard ratio of 2.5 (95% CI, 0.9-7.3). The corresponding hazard ratio for weekly use or more was 4.2 (95% CI, 1.2-14.3). The age- and sex-adjusted hazard ratios associated with any use were 1.9 (95% CI, 0.6-6.3) for cardiovascular mortality and 4.9 (95% CI, 1.6-14.7) for noncardiovascular mortality. In a comparison of 42 marijuana users and 42 other patients matched on propensity scores, there were 6 deaths among marijuana users and one among non-users (log-rank P = .06). CONCLUSIONS: These preliminary results suggest possible hazards of marijuana for patients who survive acute myocardial infarction. Although marijuana use has not been associated with mortality in other populations, it may pose particular risk for susceptible individuals with coronary heart disease.
Authors:
Kenneth J Mukamal; Malcolm Maclure; James E Muller; Murray A Mittleman
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  155     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-03-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  AIM; IM    
Affiliation:
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA. kmukamal@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Cause of Death / trends
Female
Follow-Up Studies
Humans
Incidence
Male
Marijuana Abuse / complications*,  epidemiology
Marijuana Smoking / adverse effects*
Middle Aged
Myocardial Infarction / chemically induced,  mortality*
Prognosis
Prospective Studies
Risk Factors
Survival Rate / trends
Time Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
R01 HL041016-09A1/HL/NHLBI NIH HHS; R01HL41016/HL/NHLBI NIH HHS; R21 AA014900-02/AA/NIAAA NIH HHS; R21AA014900/AA/NIAAA NIH HHS
Comments/Corrections
Comment In:
Am Heart J. 2008 Mar;155(3):395-6   [PMID:  18294471 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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