| An explanation for the worsened prognosis in some cancer patients of perioperative transfusion: the time-dependent release of biologically active growth factors from stored blood products. | |
| | |
MedLine Citation:
|
PMID: 21347776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Over 25 years ago Francis reported an association between blood transfusion and worsened cancer prognosis. Subsequently there has been much debate over whether there is in fact such an association, and if so, what is its underlying mechanism. Allogeneic blood transfusion is the most frequent allo-transplantation procedure performed on a routine basis with no prior HLA-typing. 50% of the recipients of unprocessed red cells and platelets become allo-immunised. It is our proposition that as result of normal physiological ageing and metabolic processes (with depletion of ATP and reduction of active membrane processes), there is leaching of biologically active substances from the cells into stored blood products. These leached bioactive substances have immuno-modulatory effects, which may in part explain the increased likelihood of postoperative sepsis and adult respiratory distress syndrome in transfusion recipients. They also promote cell growth and angiogenesis and may therefore have a direct effect on tumour growth. We provide evidence to support a possible hypothesis which could explain much of the conflicting clinical and experimental evidence. |
| | |
Authors:
|
Tahwinder Upile; Waseem Jerjes; Jaspal Mahil; Navdeep Upile; Holger Sudhoff; Anthony Wright; Colin Hopper |
Related Documents
:
|
15851836 - Blood viscosity changes in experimentally trypanosoma cruzi-infected rats. 6801866 - Hematologic disorders in the elderly. 3580806 - Blood viscosity in patients with bone fractures and long term bedrest. 2568806 - Hemorrheologic effects of iotrolan after intra-arterial injection in rabbits: compariso... 3631706 - Evaluation of granulocyte transfusion in healthy neonatal pony foals. 446136 - Peripheral blood flow in secundum-type atrial septal defect; preoperative and postopera... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-24 |
Journal Detail:
|
Title: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery Volume: - ISSN: 1434-4726 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002937 Medline TA: Eur Arch Otorhinolaryngol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Ear Institute, University College London, London, UK, mrtsupile@yahoo.co.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Biomechanical evaluation of four different transosseous-equivalent/suture bridge rotator cuff repair...
Next Document: Inoperable Symptomatic Recurrent Thyroid Cancers: Preliminary Result of Radiofrequency Ablation.