Document Detail

An explanation of the low lecithin/sphingomyelin ratio of amniotic fluid in early pregnancy.
MedLine Citation:
PMID:  6489582     Owner:  NLM     Status:  MEDLINE    
We have attempted to determine why the lecithin/sphingomyelin (L/S) ratio of amniotic fluid is lower than 2 during an early stage of pregnancy. We found that, at 16 wk of gestation, long before the fetal lung secretes lecithin into the amniotic fluid, the L/S ratio was about 1. High-density lipoprotein isolated from the amniotic fluid also had such a low L/S ratio. The L/S ratios of the high-density lipoprotein from umbilical cord blood and maternal blood, however, were much higher, viz. 3.7 (+/- 0.25) and 6.4 (+/- 0.33), respectively. The increase coincided with a decrease in their fluorescence polarization. We suggest that the low L/S ratio of 16 wk amniotic fluid is caused by lipolysis of its lecithin, which is derived from fetal or maternal high-density lipoproteins.
D O Gebhardt; C M van Gent; H van der Voort; B W van der Meer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  17     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-12-14     Completed Date:  1984-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  383-6     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / analysis*
Fetal Blood / analysis
Fluorescence Polarization
Gestational Age
Lipoproteins, LDL / analysis
Phosphatidylcholines / analysis*
Sphingomyelins / analysis*
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Phosphatidylcholines; 0/Sphingomyelins

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