| An explanation of the low lecithin/sphingomyelin ratio of amniotic fluid in early pregnancy. | |
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MedLine Citation:
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PMID: 6489582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have attempted to determine why the lecithin/sphingomyelin (L/S) ratio of amniotic fluid is lower than 2 during an early stage of pregnancy. We found that, at 16 wk of gestation, long before the fetal lung secretes lecithin into the amniotic fluid, the L/S ratio was about 1. High-density lipoprotein isolated from the amniotic fluid also had such a low L/S ratio. The L/S ratios of the high-density lipoprotein from umbilical cord blood and maternal blood, however, were much higher, viz. 3.7 (+/- 0.25) and 6.4 (+/- 0.33), respectively. The increase coincided with a decrease in their fluorescence polarization. We suggest that the low L/S ratio of 16 wk amniotic fluid is caused by lipolysis of its lecithin, which is derived from fetal or maternal high-density lipoproteins. |
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Authors:
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D O Gebhardt; C M van Gent; H van der Voort; B W van der Meer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 17 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-12-14 Completed Date: 1984-12-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 383-6 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amniotic Fluid
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analysis* Female Fetal Blood / analysis Fluorescence Polarization Gestational Age Humans Lipolysis Lipoproteins, LDL / analysis Phosphatidylcholines / analysis* Pregnancy Sphingomyelins / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL; 0/Phosphatidylcholines; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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