Document Detail

An explanation for the association between specific language impairment and toxemia.
MedLine Citation:
PMID:  12888308     Owner:  NLM     Status:  MEDLINE    
An association between specific language impairment (SLI) and toxemia has been detected in several studies. No clear explanation for this association has been identified to date. However, a number of potential explanations have been offered. These include: (1) toxemia causes fetal anoxia which leads to brain damage; (2) toxemia in the mother is an indication of maternal immune attack on the developing brain; (3) the association between toxemia and SLI is indirect and arises because both are consequences of a common but as yet unknown etiological factor. In this paper we present a fourth possible explanation for the association. That is, that both SLI and toxemia may be the consequence of low circulating levels of essential fatty acids. Evidence supporting this hypothesis is presented and four possible mechanisms underlying the association are discussed.
D L Drane; J Logemann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  61     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-01-20     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA.
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MeSH Terms
Brain / embryology,  growth & development
Dyslexia / blood,  etiology
Fatty Acids, Nonesterified / blood
Language Development Disorders / blood,  etiology*
Maternal-Fetal Exchange
Models, Biological
Pre-Eclampsia / blood,  complications*
Sex Characteristics
Reg. No./Substance:
0/Fatty Acids, Nonesterified

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