Document Detail


An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach.
MedLine Citation:
PMID:  16297555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Widespread visceral hypersensitivity and the overlap of symptom complexes observed in functional gastrointestinal disorders may be related to central sensitization and neuroplastic changes. A multimodal and multi-segmental model was developed to evaluate viscero-visceral hyperalgesia induced by experimental esophageal sensitization in healthy volunteers. Twelve healthy subjects were studied using a double-blinded, placebo-controlled design. The sensitivity to mechanical and heat stimulations was assessed in the proximal esophagus, duodenum and rectum before and after perfusion of the distal esophagus with acid or saline. A special-designed probe was used allowing cross-sectional ultrasound imaging during mechanical and heat stimulation of the esophagus and duodenum. Another probe was used for mechanical stimulation of the rectum. The referred somatic pain areas to gut pain stimulations were also assessed. Following acid perfusion 11 of 12 volunteers showed increased sensitivity to one or more stimulation modalities. An overall increased sensitivity to mechanical stretch in the three gut segments was seen (P=0.0001). Posthoc analysis showed that this was mainly due to increased sensitivity in the rectum (P<0.001). No changes were seen to thermal stimulations (all P-values>0.4). The somatic referred pain area to duodenal stimulations increased (P=0.04), while it was unaffected to esophageal and rectal stimulations (P>0.3). The present method demonstrated a new approach to assess multimodal sensitivity to experimental sensitization of the esophagus and related viscero-visceral hyperalgesia. Central mechanisms can explain the remote hyperalgesia to mechanical visceral stimulation and the increase in referred pain areas. The present method may be used to explore pathophysiology and pharmacological interventions in patients with visceral hypersensitivity.
Authors:
Jens Br?ndum Fr?kjaer; S?ren Due Andersen; Jeremy Gale; Lars Arendt-Nielsen; Hans Gregersen; Asbj?rn Mohr Drewes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-16
Journal Detail:
Title:  Pain     Volume:  119     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  191-200     Citation Subset:  IM    
Affiliation:
Center for Visceral Biomechanics and Pain, Aalborg Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Pain / chemically induced,  complications,  ultrasonography*
Adult
Duodenum / ultrasonography
Endosonography / instrumentation,  methods*
Esophagus / ultrasonography
Female
Gastrointestinal Tract / ultrasonography*
Humans
Hyperalgesia / chemically induced,  complications,  ultrasonography*
Image Interpretation, Computer-Assisted / methods*
Male
Middle Aged
Pain Measurement / methods*
Physical Stimulation / adverse effects,  instrumentation,  methods*
Rectum / ultrasonography
Sodium Chloride
Viscera / ultrasonography
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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