Document Detail

An experimental study of tissue reaction to hyaluronic Acid (restylane) and polymethylmethacrylate (metacrill) in the mouse.
MedLine Citation:
PMID:  23000877     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT:: The aging skin is a challenge for medical science. Plastic surgeons and dermatologists are called every day to solve problems like filling wrinkles or folds. The material used must be biocompatible because abnormal reactions may cause catastrophic results. This study analyzes the biological behavior of polymethylmethacrylate (Metacrill) and hyaluronic acid (Restylane), using a histopathologic study in mice. A prospective study was performed using 40 mice for each substance: polymethylmethacrylate or hyaluronic acid was injected into the right ear, the left ear been used as a control. Histopathologic analyses of the right ear, liver, and kidney were performed at intervals during the study and revealed the development of a granulomatous reaction with fibrosis and absorption of spheres and signs of liver and kidney sistematization for polymethylmethacrylate. A discrete cellular reaction, with less formation of fibrosis, and no giant cells were seen in the mice injected with hyaluronic acid.
Simone C Rosa; Jefferson L S Macedo; Albino V Magalhães
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  34     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-22     Citation Subset:  IM    
*Department of pathology, Brazilian Society of Plastic Surgery, Brasilia †University of Brasilia, Brasilia, Brazil.
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