Document Detail


An experimental study of tissue reaction to polymethyl methacrylate (PMMA) microspheres (Artecoll) and dimethylsiloxane (DMS) in the mouse.
MedLine Citation:
PMID:  18496421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various methods are available for the treatment of scars, wrinkles, and other cutaneous defects, and the material used must be as biocompatible as possible. This study analyzes the biological behavior of polymethyl methacrylate/bovine collagen (Artecoll) and of polydimethylsiloxane (DMS), using a histopathological study in mice. A prospective study was performed using 40 mice for each substance: polymethyl methacrylate/bovine collagen or polydimethylsiloxane was injected into the right ear, the left ear being used as a control. Histopathological analyses of the right ear, liver, and kidney were performed at intervals during the study and revealed the development of an intense granulomatous reaction of the foreign body type in the right ear, periportal and intralobular infiltrates in the liver, and interstitial nephritis and chronic pyelonephritis in the kidney for polymethyl methacrylate/bovine collagen. A variable reaction with less intense fibrosis and a reduced foreign body reaction were seen in the mice injected with polydimethylsiloxane.
Authors:
Simone Corrêa Rosa; Albino Verçosa de Magalhães; Jefferson Lessa Soares de Macedo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  30     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-06-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Brasília, Brasília, DF, Brazil. scrmacedo@yahoo.com.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Chronic Disease
Collagen / toxicity*
Dimethylpolysiloxanes / toxicity*
Drug-Induced Liver Injury / etiology,  pathology
Ear, External / drug effects*,  pathology
Fibrosis
Granuloma, Foreign-Body / etiology*,  pathology
Kidney / drug effects*,  pathology
Liver / drug effects*,  pathology
Male
Mice
Microspheres*
Nephritis, Interstitial / etiology,  pathology
Polymethyl Methacrylate / toxicity
Prospective Studies
Pyelonephritis / etiology,  pathology
Skin / drug effects,  pathology
Chemical
Reg. No./Substance:
0/Artecoll; 0/Dimethylpolysiloxanes; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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