Document Detail

An experimental study in chickens for the pathogenesis of idiopathic scoliosis.
MedLine Citation:
PMID:  8235839     Owner:  NLM     Status:  MEDLINE    
Experimentally induced scoliosis was investigated in pinealectomized chickens using pathologic and neurophysiologic means. A total of 90 chickens were tested; 30 served as a normal control, 30 received an autografted pineal body in the intramuscular tissue of the trunk, and 30 underwent pinealectomy without autograft. Scoliosis developed in all pinealectomized chickens within 2 weeks, showing gradual progression during the next 5 or 6 weeks. At 3 months, the three-dimensional spinal deformity consisted of lateral curvature and vertebral body rotation, resulting in a prominent lordoscoliosis at the thoracic level. In contrast, scoliosis developed in only 10% of the autografted chickens. Histologic examination revealed no pathologic change in the brain in either the pinealectomized scoliosis group or in the autografted nonscoliosis group. Cortical potentials in the scoliosis group were delayed, thus suggesting conduction disturbance rostral to the brain stem. Although the relationship between the cause and effect is uncertain, these findings implicate neurotransmitters or neurohormonal systems in the pineal body as a major contributing factor in this type of experimental scoliosis.
M Machida; J Dubousset; Y Imamura; T Iwaya; T Yamada; J Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Spine     Volume:  18     ISSN:  0362-2436     ISO Abbreviation:  Spine     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-22     Completed Date:  1993-12-22     Revised Date:  2009-07-09    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1609-15     Citation Subset:  IM    
Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Brain / pathology,  physiopathology
Electric Stimulation
Evoked Potentials, Somatosensory
Hindlimb / physiopathology
Pineal Gland / physiology,  transplantation
Reaction Time
Scoliosis / etiology*,  pathology,  physiopathology
Spine / radiography
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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