Document Detail

An experimental model to evaluate the in vivo response of rat seminal vesicle to electrical stimulation.
MedLine Citation:
PMID:  8938269     Owner:  NLM     Status:  MEDLINE    
This investigation demonstrated a good model to record the pressure change of rat seminal vesicle (SV) in response to electrical stimulation (ES) of lesser splanchnic nerve (LSN) in vivo. LSN was easily identified and isolated grossly. Antegrade catheterization via the SV tail to the main lumen was performed similar to the technique of i.v. catheterization, and the pressure recording was quite satisfactory. The vesicle response to ES was frequency-dependent and reproducible. Under the conditions of 10 V and 1 ms, the maximal vesicle pressure was 81.7 +/- 2.8 mmHg with 80 Hz of ES. The inhibitory response of SV to ES by clomipramine was concentration-dependent. Clomipramine (3 mg/kg) could inhibit 53% of control responses (n = 7). This experimental model is relevant to neurophysiologic and neuropharmacologic studies of SV.
J T Hsieh; C T Chien; S P Liu; C F Chen; M K Lai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  204     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  215-7     Citation Subset:  IM    
Department of Urology, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Clomipramine / pharmacology
Ejaculation / drug effects
Electric Stimulation
Rats, Wistar
Seminal Vesicles / drug effects,  innervation,  physiology*
Serotonin Uptake Inhibitors / pharmacology
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 303-49-1/Clomipramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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