Document Detail

An experimental model of pulmonary arterial granulomatous inflammation.
MedLine Citation:
PMID:  4197697     Owner:  NLM     Status:  MEDLINE    
An experimental method to investigate pulmonary granuloma formation in the guinea pig was established. Animals sensitized to human serum albumin (HSA) and challenged intravenously with HSA covalently linked to Sepharose 2B beads developed a specific granulomatous response. This intense pulmonary arterial, focally necrotizing, but mainly granulomatous inflammatory reaction developed 5 to 7 days after the administration of the HSA-bead conjugate. Unsensitized animals did not show such extensive inflammation, but rather exhibited a typical foreign body reaction to the bead. In both the experimental and control groups, the inflammatory response was indistinguishable at 14 and 21 days. Thus the initial acute inflammatory reaction was seen only in specifically sensitized animals. On the other hand, HSA alone produced no demonstrable inflammatory lesion. These observations suggest that locally retained antigen may trigger antigen-specific T (thymus-dependent) lymphocytes to release mediators which contribute to granuloma formation.
E J Kasdon; S F Schlossman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  71     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1973 Jun 
Date Detail:
Created Date:  1973-09-06     Completed Date:  1973-09-06     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Formation
Foreign Bodies / immunology*
Foreign-Body Reaction / immunology
Freund's Adjuvant
Granuloma / immunology*
Guinea Pigs
Hypersensitivity, Delayed / immunology
Mycobacterium tuberculosis / immunology
Pulmonary Artery / immunology*
Radionuclide Imaging
Serum Albumin
Serum Albumin, Radio-Iodinated
Skin Tests
T-Lymphocytes / immunology
Reg. No./Substance:
0/Gels; 0/Serum Albumin; 0/Serum Albumin, Radio-Iodinated; 9007-81-2/Freund's Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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