Document Detail

An experimental model of intraabdominal abscess in the rat.
MedLine Citation:
PMID:  6753539     Owner:  NLM     Status:  MEDLINE    
Suitable small animal models of intraabdominal abscess are not available. We have developed a reliable model of intraabdominal abscess in the rat by fasting the animal overnight, devascularizing and ligating the cecum, and injecting 2.5 X 10(8) Escherichia coli and 2.5 X 10(9) Bacteroides fragilis into the ligated cecum. This model results in 39% coli acute mortalities within 48 hours from acute peritonitis, and abscess in 76% of survivals. Subsequent abscesses are 1.0--1.5 ml in volume and contain 4 X 10(8) E coli/ml of pus and 1.4 X 10(9) B fragilis/ml. This model allows chronic evaluation of sepsis in small animals and provides a convenient means to study the abscess microenvironment.
D E Fry; R N Garrison; R D Rink; J Casey; M M DeCamp; J D Richardson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in shock research     Volume:  7     ISSN:  0195-878X     ISO Abbreviation:  Adv Shock Res     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7908298     Medline TA:  Adv Shock Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
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MeSH Terms
Abscess / etiology*
Bacteroides Infections / etiology
Bacteroides fragilis / pathogenicity
Disease Models, Animal*
Escherichia coli Infections / etiology
Peritonitis / complications
Rats, Inbred Strains

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