Document Detail


An experimental large animal model for the assessment of bioartificial liver support systems in fulminant hepatic failure.
MedLine Citation:
PMID:  12378705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pre-clinical assessment of bioartificial liver support systems requires a highly reproducible large animal model. The main objective of the present study was to develop a valid large animal model for assessing novel bioartificial liver support systems in fulminant hepatic failure. METHODS: A complete liver devascularization procedure was performed in 10 female pigs weighing 25-38 kg. Five matched pigs were sham-operated and served as controls. RESULTS: Pigs with fulminant hepatic failure developed a hyperdynamic circulation, with increased cardiac index (P(GT) < .0001), decreased systemic vascular resistance index (P(GT) < .0001) and mean arterial pressure (P(GT) = .001). Furthermore, intracranial hypertension developed (P(GT) < .0001). with increased common carotid artery flow (P(GT) < .0001) and decreased common carotid resistance (P(G) = .003). Femoral artery flow increased (P = .036). while hindleg resistance (P < .001) and renal artery resistance decreased (P = .019). Oxygen consumption (P(GT) = .050) and oxygen extraction ratio (P(GT) = .001) increased compared to controls. Arterial ammonia, venous aspartate aminotransferase and bilirubin levels increased (P(GT) < .0001, respectively). Abnormal haemostasis developed with significant loss of platelets (P(GT) = .010), decreasing fibrinogen levels (P(G) = .001) and increasing international normalized ratio (P(GT) = .012) and activated clotting time (PGT < .001). Urine became hypo-osmotic (P < .001. P(G) = .011), with decreased sodium levels (P = .08) and increased potassium levels (P(G) = .025). CONCLUSIONS: This study characterizes a reproducible large animal model for fulminant hepatic failure that seems suitable for the assessment of bioartificial liver support systems.
Authors:
L M Ytrebø; G I Nedredal; B Langbakk; A Revhaug
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  37     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-10     Completed Date:  2003-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1077-88     Citation Subset:  IM    
Affiliation:
Dept of Digestive Surgery, University Hospital Northern Norway, Tromsø. larsmy@fagmed.uit.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Chemical Analysis
Blood Coagulation Tests
Female
Hemodynamics
Intracranial Pressure / physiology
Liver Circulation / physiology
Liver Failure, Acute / blood,  therapy*
Liver Function Tests
Liver, Artificial*
Models, Animal*
Oxygen Consumption / physiology
Regional Blood Flow
Swine
Urinalysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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