| An experimental large animal model for the assessment of bioartificial liver support systems in fulminant hepatic failure. | |
| | |
MedLine Citation:
|
PMID: 12378705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Pre-clinical assessment of bioartificial liver support systems requires a highly reproducible large animal model. The main objective of the present study was to develop a valid large animal model for assessing novel bioartificial liver support systems in fulminant hepatic failure. METHODS: A complete liver devascularization procedure was performed in 10 female pigs weighing 25-38 kg. Five matched pigs were sham-operated and served as controls. RESULTS: Pigs with fulminant hepatic failure developed a hyperdynamic circulation, with increased cardiac index (P(GT) < .0001), decreased systemic vascular resistance index (P(GT) < .0001) and mean arterial pressure (P(GT) = .001). Furthermore, intracranial hypertension developed (P(GT) < .0001). with increased common carotid artery flow (P(GT) < .0001) and decreased common carotid resistance (P(G) = .003). Femoral artery flow increased (P = .036). while hindleg resistance (P < .001) and renal artery resistance decreased (P = .019). Oxygen consumption (P(GT) = .050) and oxygen extraction ratio (P(GT) = .001) increased compared to controls. Arterial ammonia, venous aspartate aminotransferase and bilirubin levels increased (P(GT) < .0001, respectively). Abnormal haemostasis developed with significant loss of platelets (P(GT) = .010), decreasing fibrinogen levels (P(G) = .001) and increasing international normalized ratio (P(GT) = .012) and activated clotting time (PGT < .001). Urine became hypo-osmotic (P < .001. P(G) = .011), with decreased sodium levels (P = .08) and increased potassium levels (P(G) = .025). CONCLUSIONS: This study characterizes a reproducible large animal model for fulminant hepatic failure that seems suitable for the assessment of bioartificial liver support systems. |
| | |
Authors:
|
L M Ytrebø; G I Nedredal; B Langbakk; A Revhaug |
Related Documents
:
|
10365815 - Hepatic arterial pulsatility index in cirrhosis: correlation with portal pressure. 4051735 - Acute portal hypertension associated with liver resection. analysis of early postoperat... 17256445 - Effect of locally applied trapidil on norepinephrine- and dinoprost-evoked hand vein co... 7444355 - Variability of hydrostatic hepatic vein and ascitic fluid pressure, and of plasma and a... 3980125 - The third heart sound. 15345485 - Effects of menstrual cycle and oral contraceptive use on calf venous compliance. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 37 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-10-10 Completed Date: 2003-02-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
|
Languages: eng Pagination: 1077-88 Citation Subset: IM |
Affiliation:
|
Dept of Digestive Surgery, University Hospital Northern Norway, Tromsø. larsmy@fagmed.uit.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Chemical Analysis Blood Coagulation Tests Female Hemodynamics Intracranial Pressure / physiology Liver Circulation / physiology Liver Failure, Acute / blood, therapy* Liver Function Tests Liver, Artificial* Models, Animal* Oxygen Consumption / physiology Regional Blood Flow Swine Urinalysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-sub...
Next Document: Observing communication skills for informed consent: an examiner's experience.