Document Detail

An experimental design approach to retrospective exposure assessment.
MedLine Citation:
PMID:  8776195     Owner:  NLM     Status:  MEDLINE    
There are several methods currently in use for retrospective estimation of quantitative exposure levels in occupational and environmental epidemiologic studies. The most popular is a job-exposure matrix approach using a combination of existing data and professional judgment. Another method is the use of statistical models based on available exposure data. The authors present an alternative approach using an experimental design in which several factors thought to affect exposure levels are identified and set at specific levels in a cross-classified design. This approach was used to estimate historical exposures to formaldehyde in a mortality study of embalmers. Exposures were estimated as a function of solution concentration, air exchange rate, and autopsied versus intact body. There were 12 combinations involving these 3 factors and a total of 25 embalming procedures (approximately 2 replicates of each combination) performed at a college of mortuary science. In addition to these design factors several covariates such as temperature, humidity, and the occurrence of spills were considered in an analysis of covariance statistical model. The results of the model prediction were validated against published measurements, and field samples were taken in several funeral homes. The overall accuracy of the model predictions was comparable to the variation found in replicate measurements of identical embalming procedures.
R W Hornung; R F Herrick; P A Stewart; D F Utterback; C E Feigley; D K Wall; D E Douthit; R B Hayes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American Industrial Hygiene Association journal     Volume:  57     ISSN:  0002-8894     ISO Abbreviation:  Am Ind Hyg Assoc J     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0371160     Medline TA:  Am Ind Hyg Assoc J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA.
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MeSH Terms
Models, Statistical*
Occupational Exposure*
Research Design
Retrospective Studies
Reg. No./Substance:

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