Document Detail

An experimental and computational analysis of primary cilia deflection under fluid flow.
MedLine Citation:
PMID:  22452422     Owner:  NLM     Status:  Publisher    
In this study we have developed a novel model of the deflection of primary cilia experiencing fluid flow accounting for phenomena not previously considered. Specifically, we developed a large rotation formulation that accounts for rotation at the base of the cilium, the initial shape of the cilium and fluid drag at high deflection angles. We utilised this model to analyse full 3D data-sets of primary cilia deflecting under fluid flow acquired with high-speed confocal microscopy. We found a wide variety of previously unreported bending shapes and behaviours. We also analysed post-flow relaxation patterns. Results from our combined experimental and theoretical approach suggest that the average flexural rigidity of primary cilia might be higher than previously reported (Schwartz et al. 1997, Am J Physiol. 272(1 Pt 2):F132-F138). In addition our findings indicate that the mechanics of primary cilia are richly varied and mechanisms may exist to alter their mechanical behaviour.
Matthew E Downs; An M Nguyen; Florian A Herzog; David A Hoey; Christopher R Jacobs
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-28
Journal Detail:
Title:  Computer methods in biomechanics and biomedical engineering     Volume:  -     ISSN:  1476-8259     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802899     Medline TA:  Comput Methods Biomech Biomed Engin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Cell and Molecular Biomechanics Laboratory, Department of Biomedical Engineering , Columbia University , 500 W 120th Street, 351 Engineering Terrace, MC 8904 , New York , NY , 10027 , USA.
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