Document Detail

The experimental and clinical use of intravitreal antibiotics to treat bacterial and fungal endophthalmitis.
MedLine Citation:
PMID:  1081447     Owner:  NLM     Status:  MEDLINE    
The experimental data involving the use of 14 antibacterial and two antifungal agents have been used to establish a rationale for the management of human endophthalmitis. Twelve cases of endophthalmitis treated under our supervision have been described in detail. The eventual visual outcome is related to two factors: (1) time interval between diagnosis and institution of adequate therapy, and (2) the severity of the organism and its ability to produce exotoxins and proteolytic enzymes. Eleven of 12 cases were cured with the recommended dosages of gentamicin and dexamethasone (400 mcg and 360 mcg, respectively). Eight of the 12 patients retained useful vision of 20/200 or better.
G A Peyman; D W Vastine; H I Meisels
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  39     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-201     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antifungal Agents / therapeutic use
Bacterial Infections / drug therapy*
Candidiasis / drug therapy*
Dexamethasone / administration & dosage,  therapeutic use
Endophthalmitis / drug therapy*,  etiology
Gentamicins / administration & dosage*,  therapeutic use
Visual Acuity
Vitreous Body
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Gentamicins; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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