Document Detail


The expanding spectrum of IgA pemphigus: a case report and a review of the literature.
MedLine Citation:
PMID:  24601812     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
IgA pemphigus (IGAP) is a rare distinct variant of pemphigus, currently classified into subcorneal pustular dermatosis (SPD) type and intraepidermal neutrophilic IgA dermatosis (IEN) types based upon histological features, immunofluorescence staining pattern and autoantibodies profile. In a patient with a widespread blistering disease of the skin resembling SPD-type IGAP, we demonstrate the coexistence of IgA reactivity to both epidermal (Dsc2/Dsc3) and basement membrane-associated (BP180) proteins, suggesting the coexistence of atypical IgA pemphigus and linear IgA bullous dermatosis, respectively. This case, together with 20 previous reports of atypical IGAP, underscores the limitations of current classification schemes. We therefore suggest to re-classify these cases under the general term "IgA pemphigus spectrum". This article is protected by copyright. All rights reserved.
Authors:
S Geller; A Gat A; T Zeeli; A Hafner; R Eming; M Hertl; E Sprecher
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-6
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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