Document Detail

The exoneme helps malaria parasites to break out of blood cells.
MedLine Citation:
PMID:  18083092     Owner:  NLM     Status:  MEDLINE    
Malaria parasites must invade the erythrocytes of its host, to be able to grow and multiply. Having depleted the host cell of its nutrients, the parasites break out to invade new erythrocytes. In this issue of Cell, Yeoh et al. (2007) discover a new organelle, the exoneme, that contains a protease SUB1, which helps the parasite to escape from old erythrocytes and invade new ones.
Chris J Janse; Andrew P Waters
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  131     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1036-8     Citation Subset:  IM    
Department of Parasitology, Leiden University Medical Centre, Albinusdreef 2, 2333ZA Leiden, The Netherlands.
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MeSH Terms
Erythrocytes / parasitology*
Host-Parasite Interactions*
Life Cycle Stages
Malaria / blood,  metabolism,  parasitology*
Plasmodium falciparum / enzymology*,  pathogenicity,  ultrastructure
Protozoan Proteins / physiology*
Subtilisins / physiology*
Reg. No./Substance:
0/Protozoan Proteins; EC 3.4.21.-/Subtilisins; EC 3.4.21.-/subtilisin-like protease 1, Plasmodium falciparum
Comment On:
Cell. 2007 Dec 14;131(6):1072-83   [PMID:  18083098 ]

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