| The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life threatening events (ALTE). | |
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MedLine Citation:
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PMID: 21334743 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation. |
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Authors:
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Jolanta Wasilewska; Edyta Sienkiewicz-Szłapka; Ewa Kuźbida; Beata Jarmołowska; Maciej Kaczmarski; Elżbieta Kostyra |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-18 |
Journal Detail:
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Title: Neuropeptides Volume: - ISSN: 1532-2785 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8103156 Medline TA: Neuropeptides Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Paediatrics, Gastroenterology and Allergic Diseases, The Medical University of Białystok, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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