| An exogenous marker: a novel approach for the characterization of oxidative stress. | |
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MedLine Citation:
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PMID: 17407818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress (OS) and its consequences which promote alterations in biomolecules, to tissue damage and to the development of pathological conditions, continue to attract many investigators. The identification of reliable biomarker is essential for the characterization of OS and possibly for early discovery of OS-associated diseases. The aim of the present study was to offer a new concept in the development of novel probes for OS, based on the design, synthesis, and utilization of exogenous markers, as alternative to the search for endogenous markers. This article describes: (a) the synthesis of such a marker, linoleoyl tyrosine 2-deoxyguanosyl ester (LTG), constructed from three endogenous subunits: linoleic acid, tyrosine, and 2'-deoxyguanosine, representing the three major groups from which the body is composed, unsaturated fatty acids (USFA), proteins, and DNA, respectively, all bound covalently and (b) the development of analytical tools (LC/MS/MS) to enable the identification of the different LTG oxidized products formed under OS by exposure of LTG to different reactive oxygen species (ROS) such as, copper ions and hypochlorous acid. |
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Authors:
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Soliman Khatib; Ramadan Musa; Jacob Vaya |
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Publication Detail:
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Type: Journal Article Date: 2007-03-21 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 15 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 3661-6 Citation Subset: IM |
Affiliation:
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The Laboratory of Natural Medicinal Compounds, Migal - Galilee Technological Center, PO Box 831, Kiryat Shmona 11016, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis Copper / chemistry Deoxyguanosine / analogs & derivatives*, chemical synthesis, chemistry Hypochlorous Acid / analysis Linoleic Acid / chemistry Linoleic Acids / chemical synthesis*, chemistry Molecular Probes / chemical synthesis, chemistry* Oxidation-Reduction Oxidative Stress* Reactive Oxygen Species / analysis* Tyrosine / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Linoleic Acids; 0/Molecular Probes; 0/Reactive Oxygen Species; 0/linoleoyl tyrosine 2-deoxyguanosyl ester; 2197-37-7/Linoleic Acid; 55520-40-6/Tyrosine; 7440-50-8/Copper; 7790-92-3/Hypochlorous Acid; 961-07-9/Deoxyguanosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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