Document Detail

The exit of some human diploid fibroblasts (WI-38 cells) from the cell cycle in early G1.
MedLine Citation:
PMID:  3719703     Owner:  NLM     Status:  MEDLINE    
The inducibility of DNA synthesis in WI-38 cells synchronized for different parts of G1 upon fusion with HeLa cells in S has been studied. In the heterokaryons 70 to 80% of WI-38 cell nuclei responded to HeLa inducers within one hour after cell fusion. The remainder of WI-38 cell nuclei responded to HeLa inducers after a lag of 3 hours or more. This lag was independent of duration of G1 traversed by WI-38 cells before cell fusion. The results of these studies suggest that 20 to 30% of WI-38 cells retire from the cell cycle in very early G1.
M V Rao
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell biology international reports     Volume:  10     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-28     Completed Date:  1986-07-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-66     Citation Subset:  IM    
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MeSH Terms
Cell Line
DNA Replication*
Fibroblasts / cytology
Hela Cells / cytology
Mitotic Index
Thymidine / metabolism
Grant Support
Reg. No./Substance:
10028-17-8/Tritium; 50-89-5/Thymidine

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