| The exit of some human diploid fibroblasts (WI-38 cells) from the cell cycle in early G1. | |
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MedLine Citation:
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PMID: 3719703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inducibility of DNA synthesis in WI-38 cells synchronized for different parts of G1 upon fusion with HeLa cells in S has been studied. In the heterokaryons 70 to 80% of WI-38 cell nuclei responded to HeLa inducers within one hour after cell fusion. The remainder of WI-38 cell nuclei responded to HeLa inducers after a lag of 3 hours or more. This lag was independent of duration of G1 traversed by WI-38 cells before cell fusion. The results of these studies suggest that 20 to 30% of WI-38 cells retire from the cell cycle in very early G1. |
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Authors:
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M V Rao |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell biology international reports Volume: 10 ISSN: 0309-1651 ISO Abbreviation: Cell Biol. Int. Rep. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-07-28 Completed Date: 1986-07-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7708050 Medline TA: Cell Biol Int Rep Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 357-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line DNA Replication* Fibroblasts / cytology Hela Cells / cytology Humans Interphase* Kinetics Metaphase Mitotic Index Thymidine / metabolism Tritium |
| Grant Support | |
ID/Acronym/Agency:
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AG 03441/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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10028-17-8/Tritium; 50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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