Document Detail

On the existence and location of cardiac mucosa: an autopsy study in embryos, fetuses, and infants.
MedLine Citation:
PMID:  12740332     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The incidence of gastric cardiac adenocarcinoma has increased in the last decades. Gaining insight into the pathogenesis of this lesion is hampered by the limited knowledge of the origin and histology of cardiac mucosa (CM). Currently, the location, extent, and even the existence of CM are controversial.
AIMS: We studied the development of the gastro-oesophageal junction (GOJ) in embryos, fetuses, and infants to clarify if CM is a normal structure at birth and where it is located.
SUBJECTS: Twenty one autopsy cases were evaluated ranging in age from 13 weeks' gestational age (GA) to seven months.
METHODS: The distal oesophagus and proximal part of the stomach were embedded entirely. Serial sections were stained with haematoxylin-eosin and alcian blue/periodic acid-Schiff. The following parameters were measured: length of abdominal oesophagus; length of columnar lined oesophagus; length of CM; and distance from CM to angle of His.
RESULTS: CM was present in all evaluated sections. Its mean length varied throughout gestation. A maximum value was reached at a GA of 16 weeks (1.2 mm). After term delivery it was very short (0.3-0.6 mm). CM was proximal to, or straddled, the angle of His in all cases. During gestation, the mucin staining pattern of the CM was to a high degree similar to that of the developing pyloric mucosa.
CONCLUSIONS: CM develops during pregnancy and is present at birth as a normal structure. If the angle of His is taken as a landmark for the GOJ, CM is located in the distal oesophagus.
G De Hertogh; P Van Eyken; N Ectors; J Tack; K Geboes
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  52     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-12     Completed Date:  2003-06-24     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  791-6     Citation Subset:  AIM; IM    
Department of Pathology, University Hospitals, Catholic University Leuven, Belgium.
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MeSH Terms
Aging / pathology
Cardia / anatomy & histology,  embryology*,  growth & development
Embryonic and Fetal Development
Esophagogastric Junction / anatomy & histology,  embryology,  growth & development
Gastric Mucosa / anatomy & histology,  embryology*,  growth & development
Infant, Newborn
Comment In:
Gut. 2003 Dec;52(12):1798; author reply 1798-9   [PMID:  14633968 ]

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