Document Detail


The exercising heart at altitude.
MedLine Citation:
PMID:  19809792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maximal cardiac output is reduced in severe acute hypoxia but also in chronic hypoxia by mechanisms that remain poorly understood. In theory, the reduction of maximal cardiac output could result from: (1) a regulatory response from the central nervous system, (2) reduction of maximal pumping capacity of the heart due to insufficient coronary oxygen delivery prior to the achievement of the normoxic maximal cardiac output, or (3) reduced central command. In this review, we focus on the effects that acute and chronic hypoxia have on the pumping capacity of the heart, particularly on myocardial contractility and the molecular responses elicited by acute and chronic hypoxia in the cardiac myocytes. Special emphasis is put on the cardioprotective effects of chronic hypoxia.
Authors:
José A L Calbet; Paul Robach; Carsten Lundby
Publication Detail:
Type:  Journal Article; Review     Date:  2009-10-07
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  66     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3601-13     Citation Subset:  IM    
Affiliation:
Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira, 35017, Las Palmas de Gran Canaria, Canary Islands, Spain. lopezcalbet@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Altitude*
Animals
Anoxia / physiopathology
Cytoprotection / physiology
Exercise / physiology*
Heart / physiology*
Humans
Myocardial Contraction / physiology
Myocardial Reperfusion Injury / prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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