Document Detail

The exercise redox paradigm in the Down's syndrome: improvements in motor function and increases in blood oxidative status in young adults.
MedLine Citation:
PMID:  18795225     Owner:  NLM     Status:  MEDLINE    
Considerable evidence has indicated a pro-oxidant status in the brain of people with Down's syndrome (DS), which may contribute to motor and cognitive impairments verified in this condition. On the other hand, previous studies addressing the role of physical exercise on oxidative stress and antioxidant status in DS have indicated conflicting results. Here, we investigated the effects of a supervised judo training of controlled intensity and monitored on the basis of lactate threshold on the blood oxidative stress status and motor coordination in 21 young adults with DS. The training extended over a period of 16 weeks and consisted of three sessions per week. The exercise improved the motor function and significantly decreased lactate production in the DS subjects. However, blood markers of oxidative damage to lipids (TBARS and lipid peroxides) and proteins (carbonyls) were increased by the judo training. Moreover, superoxide dismutase and catalase activity also increased, while glutathione peroxidase activity remained unaltered after exercise. These results reinforce the notion that physical exercise can improve motor disabilities in people with DS. More importantly, our findings demonstrate that the beneficial effects are accompanied by some degree of oxidative stress, suggesting that young adults with DS may be more susceptible to physical training-induced oxidative stress than adolescents with DS, which should be taken into account in physical training programs for this population.
Aderbal S Aguiar; Talita Tuon; Mirella M Albuquerque; Gláucia S Rocha; Ana E Speck; Júlio C Araújo; Alcir L Dafré; Rui D S Prediger; Ricardo A Pinho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-16
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  115     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1643-50     Citation Subset:  IM    
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianópolis, SC, 88049-900, Brazil.
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MeSH Terms
Antioxidants / metabolism
Biological Markers / blood
Brain / metabolism,  physiopathology
Brain Diseases, Metabolic, Inborn / metabolism,  physiopathology,  therapy*
Catalase / blood
Down Syndrome / complications*,  metabolism,  physiopathology
Exercise Therapy / adverse effects
Exercise Tolerance / physiology*
Lactic Acid / blood
Lipid Peroxidation / physiology
Movement Disorders / metabolism,  physiopathology,  therapy*
Oxidative Stress / physiology*
Physical Fitness / physiology*
Superoxide Dismutase / blood
Thiobarbituric Acid Reactive Substances / metabolism
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Thiobarbituric Acid Reactive Substances; 50-21-5/Lactic Acid; EC; EC Dismutase

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