Document Detail

An exercise intervention for breast cancer survivors with bone loss.
MedLine Citation:
PMID:  19335674     Owner:  NLM     Status:  MEDLINE    
PURPOSE: (a) to determine if 110 postmenopausal breast cancer survivors (BCS) with bone loss who participated in 24 months of strength and weight training (ST) exercises had improved muscle strength and balance and had fewer falls compared to BCS who did not exercise; and (b) to describe type and frequency of ST exercises; adverse effects of exercises; and participants' adherence to exercises at home, at fitness centers, and at 36-month follow up. DESIGN: Findings reported are from a federally funded multicomponent intervention study of 223 postmenopausal BCS with either osteopenia or osteoporosis who were randomly assigned to an exercise (n=110) or comparison (n=113) group. METHODS: Time points for testing outcomes were baseline, 6, 12, and 24 months into intervention. Muscle strength was tested using Biodex Velocity Spectrum Evaluation, and dynamic balance using Timed Backward Tandem Walk. Adherence to exercises was measured using self-report of number of prescribed sessions attended and participants' reports of falls. FINDINGS: Mean adherence over 24 months was 69.4%. Using generalized estimating equation (GEE) analyses, compared to participants not exercising, participants who exercised for 24 months had significantly improved hip flexion (p=0.011), hip extension (p=0.0006), knee flexion (p<0.0001, knee extension (p=0.0018), wrist flexion (p=0.031), and balance (p=0.010). Gains in muscle strength were 9.5% and 28.5% for hip flexion and extension, 50.0% and 19.4% for wrist flexion and extension, and 21.1% and 11.6% for knee flexion and extension. Balance improved by 39.4%. Women who exercised had fewer falls, but difference in number of falls between the two groups was not significant. CONCLUSIONS: Many postmenopausal BCS with bone loss can adhere to a 24 month ST exercise intervention, and exercises can result in meaningful gains in muscle strength and balance. CLINICAL RELEVANCE: More studies are needed for examining relationships between muscle strength and balance in postmenopausal BCS with bone loss and their incidence of falls and fractures.
Janice J Twiss; Nancy L Waltman; Kris Berg; Carol D Ott; Gloria J Gross; Ada M Lindsey
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau     Volume:  41     ISSN:  1547-5069     ISO Abbreviation:  J Nurs Scholarsh     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100911591     Medline TA:  J Nurs Scholarsh     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM; N    
University of Nebraska Medical Center College of Nursing, Omaha, NE, USA.
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MeSH Terms
Breast Neoplasms / epidemiology*,  therapy*
Middle Aged
Muscle, Skeletal
Osteoporosis / epidemiology*
Survivors / statistics & numerical data*
Grant Support
1 R01 NR07743-01A1/NR/NINR NIH HHS

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