| The executioners sing a new song: killer caspases activate microglia. | |
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MedLine Citation:
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PMID: 21836616 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of neurodegenerative disorders. We discuss possible underlying mechanisms regulating their activation and neurotoxic effect. We focus on the provocative hypothesis that caspase inhibition can be neuroprotective by targeting the microglia rather than the neurons themselves.Cell Death and Differentiation advance online publication, 12 August 2011; doi:10.1038/cdd.2011.107. |
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Authors:
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J L Venero; M A Burguillos; P Brundin; B Joseph |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-12 |
Journal Detail:
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Title: Cell death and differentiation Volume: - ISSN: 1476-5403 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9437445 Medline TA: Cell Death Differ Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Facultad de Farmacia, Departamento de Bioquímica y Biología Molecular, Universidad de Sevilla, and Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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