Document Detail

The excitatory response of the adrenal sympathetic nerve to severe hypoxia decreases in aged rats.
MedLine Citation:
PMID:  8255557     Owner:  NLM     Status:  MEDLINE    
The age-related changes in the sensitivity of the adrenal sympathetic nerve to hypoxia were investigated in anesthetized young adult (3-4 months old) and aged rats (25-26 months old). Hypoxia with end-tidal O2 concentration (FETO2) at 6-2% caused excitation of adrenal nerve activity in the young adult and the aged rats. There was a significant decrease in the responses at 3 and 2% FETO2 in the aged rats compared to the young adult rats at either peripheral chemoreceptors-intact or -denervated condition. Reduced responsiveness of the central chemoreceptors to severe hypoxia is suggested as a possible factor in the age-related decreases.
A Sato; A Trzebski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  161     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-07     Completed Date:  1994-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Department of the Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Japan.
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MeSH Terms
Adrenal Medulla / innervation*
Anoxia / physiopathology*
Chemoreceptor Cells / physiopathology
Rats, Wistar
Sympathetic Nervous System / physiopathology*

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