Document Detail

An excess of tetralogy of Fallot in Malta.
MedLine Citation:
PMID:  9764276     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To estimate birth prevalence of tetralogy of Fallot (TF) in Malta. DESIGN: Retrospective data collection and analysis, and comparison with earlier epidemiological studies dealing with congenital heart disease. SETTING: Regional hospital providing exclusive diagnostic and follow up services for the entire country of Malta. PATIENTS: All Maltese live births diagnosed as having TF. MAIN RESULTS: The birth prevalence of TF in Malta for the period 1980-1994 was 0.64/1000 live births (95% confidence intervals 0.48, 0.85/1000 live births). This was significantly higher than previously reported in the medical literature. CONCLUSIONS: The Maltese gene pool seems to have a genetic predisposition towards live births with TF. Population genetic studies with emphasis on the prevalence of 22q11 microdeletion may yield clues regarding the cause of the high rate of this condition.
V Grech
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  52     ISSN:  0143-005X     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-10-28     Completed Date:  1998-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  280-2     Citation Subset:  IM    
Paediatric Department, St Lukes Hospital, Guardamangia, Malta.
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MeSH Terms
Infant, Newborn
Malta / epidemiology
Retrospective Studies
Tetralogy of Fallot / epidemiology*

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