| The exact distribution of divergence times. | |
| | |
MedLine Citation:
|
PMID: 17914656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The recent work of Haubold and Wiehe (Mol. Biol. Evol. 18:1157-1160, 2001) considered statistical inference of the divergence time. However, there appears to be a fundamental flaw in the paper since it treated the divergence time as a random variable and not as a parameter. In this note, we derive a valid statistical inference for the divergence time. We derive an estimator for the divergence time as well as explicit expressions for its the probability density function, cumulative distribution function and the means. We also provide a 5-line computer program for computing the associated confidence intervals. We expect that the results presented could be useful for statistical modeling of divergence times. |
| | |
Authors:
|
Saralees Nadarajah; Samuel Kotz |
Related Documents
:
|
8142996 - Measuring utility values for qalys: two methodological issues. 18243446 - Assessment of the uncertainties in the radiological protection institute of ireland (rp... 15936746 - The bootstrap: a technique for data-driven statistics. using computer-intensive analyse... 18832356 - A simple formula for obtaining markedly improved mutation rate estimates. 17855216 - Chemistry across scales: from molecules to cells. 23696286 - Photoluminescence of titanosilsesquioxanes in solution and its relevance for the unders... |
Publication Detail:
|
Type: Journal Article Date: 2007-10-04 |
Journal Detail:
|
Title: Bulletin of mathematical biology Volume: 70 ISSN: 0092-8240 ISO Abbreviation: Bull. Math. Biol. Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-21 Completed Date: 2008-04-11 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0401404 Medline TA: Bull Math Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 635-40 Citation Subset: IM |
Affiliation:
|
School of Mathematics, University of Manchester, Manchester M60 1QD, UK saralees.nadarajah@manchester.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Substitution
/
genetics Chronobiology Phenomena / genetics* Confidence Intervals Evolution, Molecular Genetic Speciation* Likelihood Functions Models, Statistical Phylogeny Polymorphism, Genetic Statistical Distributions* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Earlier eradication of intra-anal warts with argon plasma coagulator combined with imiquimod cream c...
Next Document: Sensory irritation response in rats: modeling, analysis and validation.