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An ex vivo study of selenium, genistein on the morphological and nuclear changes in anticancer drug-induced apoptosis in human peripheral blood lymphocytes.
MedLine Citation:
PMID:  23355315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Behavioral difference of cancer cells and normal cells to anticancer drugs is diverse. Debilitating side effects observed with certain chemotherapeutic and prophylactic anticancer drugs have lead to identification of natural agents that may offer protective role against the damage induced in normal cells. The present study aimed to determine the protective role of the micronutrient mineral selenium (Se) and plant product genistein (Gn) in synergy and single, against the apoptosis induced in human peripheral blood lymphocytes by the cytotoxic agents cisplatin and mitomycin C. We observed reduction in apoptotic potential of cisplatin and mitomycin C in lymphocytes by pre-treatment and post-treatment with selenium (30 μM) and genistein (100 μM). The intercellular interaction of Se + Gn in synergy is found to be more efficient in protecting lymphocytes than as individual. Moreover the beneficial results were well pronounced in pre-treatment than in post-treatment condition. The protective action of these natural compounds suggests that they might be useful immunomodulators during the course of chemotherapy and prophylaxis. © 2013 BioFactors, 2013.
Authors:
Elango Sonaa; Subbiah Usha; Jeong Ja In
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  -     ISSN:  1872-8081     ISO Abbreviation:  Biofactors     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
Affiliation:
Department of Biomedical Sciences, College of Natural Sciences, Catholic University of Daegu, Hayang-eup, Gyeongsan-si, Gyeongbuk, Republic of Korea; Department of Medical Research, SRM Medical College and Hospital and Research Centre, SRM University, Potheri, Tamil Nadu, India. sonaacumed@rediffmail.com, chonaa_2004@yahoo.co.in.
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