Document Detail


The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activities.
MedLine Citation:
PMID:  7931263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) activities were examined in homogenates of various rat tissues following i.p. administration of procarbazine or methylhydrazine. Both compounds inhibited SSAO in a dose-dependent manner in all tissues examined, with methylhydrazine the more potent agent in this respect. Little inhibition of MAO could be detected in most cases. However, hepatic MAO-B activity was potentiated significantly in rats receiving methylhydrazine and both drugs caused a dose-dependent potentiation of MAO-A in homogenates of brown adipose tissue. The potential use of these compounds in vivo as selective SSAO inhibitors is discussed.
Authors:
A Holt; B A Callingham
Related Documents :
15565253 - The lycopodium alkaloids.
7931263 - The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activ...
1318723 - Cerebellar gabaa receptors in two rat lines selected for high and low sensitivity to mo...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. Supplementum     Volume:  41     ISSN:  0303-6995     ISO Abbreviation:  J. Neural Transm. Suppl.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-23     Completed Date:  1994-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425126     Medline TA:  J Neural Transm Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Cambridge, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / enzymology
Amine Oxidase (Copper-Containing)*
Animals
Dose-Response Relationship, Drug
Liver / enzymology
Male
Monoamine Oxidase / metabolism
Monoamine Oxidase Inhibitors / pharmacology
Monomethylhydrazine / pharmacology*
Myocardium / enzymology
Oxidoreductases Acting on CH-NH Group Donors / antagonists & inhibitors*
Procarbazine / pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 60-34-4/Monomethylhydrazine; 671-16-9/Procarbazine; EC 1.4.3.4/Monoamine Oxidase; EC 1.4.3.6/Amine Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Location of the active site of rat vascular semicarbazide-sensitive amine oxidase.
Next Document:  Histaminase activity of mesenteric artery of the rat.