Document Detail

The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activities.
MedLine Citation:
PMID:  7931263     Owner:  NLM     Status:  MEDLINE    
Monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) activities were examined in homogenates of various rat tissues following i.p. administration of procarbazine or methylhydrazine. Both compounds inhibited SSAO in a dose-dependent manner in all tissues examined, with methylhydrazine the more potent agent in this respect. Little inhibition of MAO could be detected in most cases. However, hepatic MAO-B activity was potentiated significantly in rats receiving methylhydrazine and both drugs caused a dose-dependent potentiation of MAO-A in homogenates of brown adipose tissue. The potential use of these compounds in vivo as selective SSAO inhibitors is discussed.
A Holt; B A Callingham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. Supplementum     Volume:  41     ISSN:  0303-6995     ISO Abbreviation:  J. Neural Transm. Suppl.     Publication Date:  1994  
Date Detail:
Created Date:  1994-11-23     Completed Date:  1994-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425126     Medline TA:  J Neural Transm Suppl     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  439-43     Citation Subset:  IM    
Department of Pharmacology, University of Cambridge, United Kingdom.
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MeSH Terms
Adipose Tissue, Brown / enzymology
Amine Oxidase (Copper-Containing)*
Dose-Response Relationship, Drug
Liver / enzymology
Monoamine Oxidase / metabolism
Monoamine Oxidase Inhibitors / pharmacology
Monomethylhydrazine / pharmacology*
Myocardium / enzymology
Oxidoreductases Acting on CH-NH Group Donors / antagonists & inhibitors*
Procarbazine / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Monoamine Oxidase Inhibitors; 60-34-4/Monomethylhydrazine; 671-16-9/Procarbazine; EC Oxidase; EC Oxidase (Copper-Containing); EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors

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