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The evolving epidemiology of valvular aortic stenosis. The Tromso Study.
MedLine Citation:
PMID:  22942293     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess prevalence, incidence, prognosis and progression of degenerative valvular aortic stenosis (AS). SETTING: The Tromsø Study and the University Hospital of North Norway. DESIGN: Population based prospective study. POPULATION: Over a 14 year span we performed three repeated echocardiographic examinations (1994, 2001 and 2008) of a random sample of initially 3273 participants. Data from the only hospital serving this population were included. RESULTS: There were 164 subjects with AS. Prevalence consistently increased with age, average values being 0.2% in the 50-59 year cohort, 1.3% in the 60-69 year cohort, 3.9% in the 70-79 year cohort and 9.8% in the 80-89 year cohort. The incidence rate in the study was 4.9‰/year. The mean annual increase in mean transvalvular pressure gradient was 3.2 mm Hg. The increase was lower in mild AS than in more severe disease, disclosing a non-linear development of the gradient, but with large individual variations. Mortality was not significantly increased in the asymptomatic AS-group (HR=1.28), nor in those who received aortic valve replacement (n=34, HR=0.93), compared with the general population. CONCLUSION: This is the first study to document the incidence and prognosis of AS in a general population with surgery as a treatment option. It reveals an accelerated progression of the aortic mean gradient as the disease advances. The prognosis of AS seems to be comparable with the normal population in the asymptomatic stage and after successful surgery, indicating that the follow-up and timing of surgery has been adequate for this patient group.
Gry Wisthus Eveborn; Henrik Schirmer; Geir Heggelund; Per Lunde; Knut Rasmussen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-2
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  -     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Cardiothoracic and Respiratory Medicine, University Hospital of Northern Norway, Tromsø, Norway.
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