Document Detail

The evolutionary origins of maternal calcium and bone metabolism during lactation.
MedLine Citation:
PMID:  12751891     Owner:  NLM     Status:  MEDLINE    
Calcium is required for skeletal growth in all vertebrate offspring. In eutherian mammals, calcium is provided by the mother via the placenta during fetal growth and via milk until weaning. Transferring calcium to offspring during pregnancy and lactation significantly stresses maternal calcium homeostasis. During human pregnancy, the extra calcium requirements are met primarily by an increase in absorption of calcium from the diet and by a modest increase in rates of bone resorption. In nursing mothers, the calcium required for milk production is generated by a dramatic increase in rates of bone resorption and a decrease in the rate of renal calcium excretion. To consider the evolution of these maternal adaptations in bone and calcium metabolism, comparisons are made across different species of mammals, and the fundamental problem of maternal transfer of calcium to young is explored in lower vertebrates. These comparisons suggest that maternal adaptations in calcium and bone metabolism during pregnancy and lactation in mammals originate from adaptations in bone and mineral metabolism that supply calcium for egg production in lower vertebrates.
John J Wysolmerski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  7     ISSN:  1083-3021     ISO Abbreviation:  J Mammary Gland Biol Neoplasia     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2004-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-76     Citation Subset:  IM    
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, FMP 102, 333 Cedar Street, New Haven, Connecticut 06520, USA.
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MeSH Terms
Bone Density / physiology*
Bone and Bones / metabolism*
Calcium / metabolism*
Lactation / metabolism*
Pregnancy / metabolism*
Grant Support
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