| An evolutionary model for identifying genetic adaptation to high altitude. | |
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MedLine Citation:
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PMID: 17089883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coordinated maternal/fetal responses to pregnancy are required to ensure continuous O2 delivery to the developing organism. Mammals employ distinctive reproductive strategies that afford their young an improved chance of survival through the completion or the reproductive period. Thus, mortality prior to the end of the reproductive period is concentrated in the earliest phases of the lifecycle. At high altitude, fetal growth restriction reduces birth weight and likely compromises survival during the early postnatal period. Population variation in the frequency of the altitude-associated increase in intrauterine growth restriction (IUGR) demonstrates that multigenerational Tibetan and Andean high-altitude populations are protected compared with shorter duration, European or Han (Chinese) residents. This experiment of nature permits testing the hypothesis that genetic factors (a) influence susceptibility to altitude-associated IUGR, (b) act on maternal vascular adjustments to pregnancy determining uteroplacental blood flow, and (c) involve genes which regulate and/or are regulated by hypoxia-inducible factors (HIFs). Serial, studies during pregnancy as well as postpartum in Andean and European residents of high (3600 m) and low (300 m) altitude will permit evaluation of whether uteroplacental O2 delivery is lower in the European than Andean women and, if so, the physiological factors responsible. Comparisons of HIF-targeted vasoactive substances and SNPs in or near HIF-regulatory or targeted genes will permit determination of whether these regions are distinctive in the Andean population. Studies coupling genetic and genomic approaches with more traditional physiological measures may be productively employed for determining the genetic mechanisms influencing physiological adaptation to high altitude. |
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Authors:
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Lorna G Moore; Mark Shriver; Lynne Bemis; Enrique Vargas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 588 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-08 Completed Date: 2006-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 101-18 Citation Subset: IM |
Affiliation:
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Colorado Center for Altitude Medicine and Physiology, Division of Emergency Medicine, USA. Lorna.G.Moore@UCHSC.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Altitude* Anoxia Child Child, Preschool Evolution* Female Fetal Growth Retardation / pathology Humans Hypoxia-Inducible Factor 1 / metabolism Infant Infant, Newborn Ischemia / pathology Middle Aged Models, Biological Models, Genetic* Oxygen / metabolism Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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