Document Detail

The evolutionary conservation of eukaryotic gene transcription.
MedLine Citation:
PMID:  2680577     Owner:  NLM     Status:  MEDLINE    
The basic components required for eukaryotic gene transcription have been highly conserved in evolution. Structural and functional homology has now been documented among promoters, promoter factors, regulatory proteins, and RNA polymerases from eukaryotes as diverse as yeast and mammals. The ability of these proteins and DNA sequences to function across phylogenetic boundaries demonstrates that common molecular mechanisms underlie gene control in all eukaryotic cells, and provides the basis for powerful new approaches to the study of eukaryotic gene transcription.
M Schena
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experientia     Volume:  45     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-27     Completed Date:  1989-11-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  972-83     Citation Subset:  IM; S    
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
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MeSH Terms
Cells / metabolism*
DNA / genetics
DNA-Directed DNA Polymerase
DNA-Directed RNA Polymerases / metabolism
Eukaryotic Cells / metabolism*
Fungal Proteins / genetics
Gene Expression Regulation
Promoter Regions, Genetic / genetics
Transcription Factors / physiology
Transcription, Genetic / genetics*
Reg. No./Substance:
0/Fungal Proteins; 0/Transcription Factors; 9007-49-2/DNA; EC RNA Polymerases; EC DNA Polymerase

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