Document Detail

The evolution of oxidative stress indicators in the course of myocardial ischemia.
MedLine Citation:
PMID:  2060839     Owner:  NLM     Status:  MEDLINE    
Two studies were carried out in patients suffering from Unstable Angina (UA) and Myocardial Infarction (MI). The first study investigated the variations of the Malondialdehyde (MDA) rate at 1st, 5th, 12th day of treatment in 27 patients (15 UA and 12 MI), compared to 15 controls. This rate varied in a different way, with a first peak and a rapid decrease in UA, where it regularly decreases in MI. The second study focused on the variations of MDA, Superoxide Dismutase (SOD), Glutathion Peroxydase (GPX) rates at 2nd, 12th days in 53 patients (19 UA and 34 MI), compared to 35 controls. Here again, the rate of MDA was high on day 2 and decreased on day 12. The rate of GPX showed similar evolution while the SOD rate had an opposite evolution. These two studies confirm the evidence of oxidative stress in acute coronary deficiency.
J Loeper; J Goy; J M Klein; M Dufour; O Bedu; S Loeper; J Emerit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research communications     Volume:  12-13 Pt 2     ISSN:  8755-0199     ISO Abbreviation:  Free Radic. Res. Commun.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-07     Completed Date:  1991-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709453     Medline TA:  Free Radic Res Commun     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  675-80     Citation Subset:  IM    
Service de Médecine Interne du Professeur J. Emerit, Hôpital de La Salpétrière, Paris, France.
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MeSH Terms
Angina, Unstable / blood*
Erythrocytes / enzymology
Glutathione Peroxidase / blood
Malondialdehyde / blood
Middle Aged
Myocardial Infarction / blood*
Oxygen / metabolism*
Superoxide Dismutase / blood
Reg. No./Substance:
542-78-9/Malondialdehyde; 7782-44-7/Oxygen; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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