Document Detail

The evolution and outcome of cavitating periventricular leukomalacia in infancy. A study of 46 cases.
MedLine Citation:
PMID:  3264854     Owner:  NLM     Status:  MEDLINE    
Forty six infants with the ultrasonic diagnosis of cavitating periventricular leukomalacia (CPVL) have been reviewed. Follow up examination results allow correlation between the ultrasound appearances and subsequent neurodevelopmental and neurological deficits. The highest incidence of this condition was found in infants at and below 27 weeks gestation, and occurred in 15% of very premature infants surviving 14 days or more. Cavities developed 15 days after the onset of periventricular echodensity (median time). Ventricular dilatation occurred in 24% of the infants who developed cavities. Follow up information was available in 27 infants and 18 of these (67%) had significant neurodevelopmental handicap. The location of echolucent cavities were described as involving anterior, middle or posterior cerebral zones or any combination of these. Cerebral palsy was closely related to the presence of cavities, but there was little association between cavities and developmental delay. Four factors were found to predict cerebral palsy: cavities within the occipital zone, the involvement of multiple regions of the brain, lesions greater than 1 cm in diameter and cavities associated with subcortical leukomalacia. Lesions confined to the anterior or middle zones were unlikely to be associated with significant handicap. The presence of cavities per se was not associated with a higher incidence of severe developmental delay.
D Shortland; M I Levene; J Trounce; Y Ng; M Graham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  16     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
Department of Child Health, Leicester University School of Medicine, Great Britain.
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MeSH Terms
Cerebral Palsy / etiology
Cohort Studies
Encephalomalacia / physiopathology*
Follow-Up Studies
Infant, Newborn
Infant, Premature*
Leukomalacia, Periventricular / complications,  epidemiology,  physiopathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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