| The evolution of cellular computing: nature's solution to a computational problem. | |
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MedLine Citation:
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PMID: 10636025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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How do cells and nature 'compute'? They read and 'rewrite' DNA all the time, by processes that modify sequences at the DNA or RNA level. In 1994, Adleman's elegant solution to a seven-city directed Hamiltonian path problem using DNA launched the new field of DNA computing, which in a few years has grown to international scope. However, unknown to this field, two ciliated protozoans of the genus Oxytricha had solved a potentially harder problem using DNA several million years earlier. The solution to this problem, which occurs during the process of gene unscrambling, represents one of nature's ingenious solutions to the problem of the creation of genes. RNA editing, which can also be viewed as a computational process, offers a second algorithm for the construction of functional genes from encrypted pieces of the genome. |
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Authors:
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L F Landweber; L Kari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Bio Systems Volume: 52 ISSN: 0303-2647 ISO Abbreviation: BioSystems Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-02-25 Completed Date: 2000-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0430773 Medline TA: Biosystems Country: IRELAND |
Other Details:
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Languages: eng Pagination: 3-13 Citation Subset: IM |
Affiliation:
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Ecology and Evolutionary Biology, Princeton University, NJ 08544-1003, USA. lfl@princeton.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA, Protozoan / genetics* Evolution, Molecular* Gene Rearrangement Mutation Oxytricha / genetics* RNA Editing |
| Chemical | |
Reg. No./Substance:
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0/DNA, Protozoan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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