Document Detail

On the evidence for seasonal variation in the onset of acute lymphoblastic leukemia (ALL).
MedLine Citation:
PMID:  17481728     Owner:  NLM     Status:  MEDLINE    
Inconsistent seasonal patterns in peak presentation of acute lymphoblastic leukemia have been reported but no formal synthesis of published reports has been attempted to date. We extracted monthly tabulations of cases from publications and reanalysed using an angular methodology and the von Mises distribution. Twenty-four articles from 11 countries in locations ranging from 35.05 degrees S to 65.01 degrees N were identified. Formal synthesis established weak evidence for seasonality in adults and children. Were seasonality present, and arising from a climatic determinant, one might anticipate peaks of an increasing magnitude as the associated latitude moved away from the equator. No such pattern was apparent.
Fei Gao; Kee-Seng Chia; David Machin
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-05-04
Journal Detail:
Title:  Leukemia research     Volume:  31     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1327-38     Citation Subset:  IM    
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.
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MeSH Terms
Age Factors
Age of Onset
Child, Preschool
Infant, Newborn
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology*

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