Document Detail

The evidence for a role of B cells in multiple sclerosis.
MedLine Citation:
PMID:  22411958     Owner:  NLM     Status:  MEDLINE    
Understanding the pathogenesis of complex immunologic disorders such as multiple sclerosis (MS) is challenging. Abnormalities in many different cell types are observed in the immune system and CNS of patients with MS and the identification of the primary and secondary events is difficult. Recent studies suggest that the model of MS as a disorder mediated only by T cells is overly simplistic and propose an important role for B cells in the propagation of the disease. B-cell activation in the form of oligoclonal bands (OCB) production is the most consistent immunologic finding in patients with MS. Notably, markers of B-cell activation within the CSF of patients with MS predict conversion from clinically isolated syndrome to clinically definite MS and correlate with MRI activity, onset of relapses, and disability progression. In addition, the main genetic risk factor in MS is associated with OCB production, and environmental agents associated with MS susceptibility (vitamin D and the Epstein-Barr virus) influence B-cell proliferation and function. Finally, the only cell-specific treatments that are effective in patients with MS are monoclonal antibodies targeting the B-cell antigen CD20, suggesting a potentially causative role for B cells. Based on current evidence there is no longer doubt that B cells are relevant to the etiology and pathogenesis of MS. Elucidating the role of B cells in MS will be a fruitful strategy for disease prevention and treatment.
G Disanto; J M Morahan; M H Barnett; G Giovannoni; S V Ramagopalan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurology     Volume:  78     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-04-23     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  823-32     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Monoclonal / therapeutic use
Antigens, CD20 / drug effects
B-Lymphocytes / immunology*,  pathology*
CD4-Positive T-Lymphocytes / immunology,  pathology
Disease Progression
Epstein-Barr Virus Infections / complications
Lymphocyte Activation / immunology
Magnetic Resonance Imaging
Multiple Sclerosis / immunology,  pathology*
Oligoclonal Bands
Risk Factors
Vitamin D Deficiency / complications
Grant Support
075491/Z/04//Wellcome Trust; G0801975//Medical Research Council
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD20; 0/Oligoclonal Bands

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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