Document Detail

The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle.
MedLine Citation:
PMID:  3802197     Owner:  NLM     Status:  MEDLINE    
The midblastula transition (MBT) in Xenopus can be initiated prematurely by blocking the fundamental cell-cycle oscillator with cycloheximide, in which case motility and transcription are quickly initiated. Using various inhibitors of specific events of the cell cycle that do not inhibit the autonomous oscillator, we have shown that transcription is activated when DNA synthesis is interrupted and motility is activated when cell cleavage is inhibited. Furthermore, very low levels of transcription are found to occur before the MBT. These results demonstrate that the pre-MBT egg is fully competent for transcription and motility and suggest that different features of the rapid early cell cycle normally suppress these events.
D Kimelman; M Kirschner; T Scherson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  48     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-17     Completed Date:  1987-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
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MeSH Terms
Blastocyst / cytology*,  metabolism
Cell Cycle
Cell Movement
DNA Replication
Protein Biosynthesis
Transcription, Genetic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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