| The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle. | |
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MedLine Citation:
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PMID: 3802197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The midblastula transition (MBT) in Xenopus can be initiated prematurely by blocking the fundamental cell-cycle oscillator with cycloheximide, in which case motility and transcription are quickly initiated. Using various inhibitors of specific events of the cell cycle that do not inhibit the autonomous oscillator, we have shown that transcription is activated when DNA synthesis is interrupted and motility is activated when cell cleavage is inhibited. Furthermore, very low levels of transcription are found to occur before the MBT. These results demonstrate that the pre-MBT egg is fully competent for transcription and motility and suggest that different features of the rapid early cell cycle normally suppress these events. |
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Authors:
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D Kimelman; M Kirschner; T Scherson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 48 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-17 Completed Date: 1987-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 399-407 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / cytology*, metabolism Cell Cycle Cell Movement DNA Replication Protein Biosynthesis Transcription, Genetic* Xenopus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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