Document Detail

An event-related potential study of attention and recognition memory in infants with iron-deficiency anemia.
MedLine Citation:
PMID:  17671043     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this work was to determine whether iron-deficiency anemia in infancy represents a risk factor for deficits in attention and memory development using event-related potentials.
METHODS: Artifact-free event-related potential data were obtained at 9 and/or 12 months from 15 infants with iron-deficiency anemia and 19 who were iron sufficient during a test of the infant's ability to discriminate a highly familiar stimulus, the mother's face, from a stranger's face.
RESULTS: A midlatency negative component associated with attention and a late-occurring positive slow wave associated with memory updating were identified at both ages in the iron-deficiency anemia and iron-sufficient groups. Consistent with the age-appropriate pattern of development at 9 months, the iron-sufficient group showed a greater attentional response (negative component) to the mother and a greater updating of memory for the stranger (positive slow wave). This pattern of responses was not evident in the iron-deficiency anemia group until 12 months, suggesting a delay in cognitive development.
CONCLUSIONS: These data suggest that iron-deficiency anemia adversely affects the allocation of neurophysiologic resources to attention and recognition memory during the processing of information about familiar and unfamiliar stimuli. This delay in cognitive development may reflect alterations in efficiency of central nervous system functions that seem related to early iron deficiency.
Matthew J Burden; Alissa J Westerlund; Rinat Armony-Sivan; Charles A Nelson; Sandra W Jacobson; Betsy Lozoff; Mary Lu Angelilli; Joseph L Jacobson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  120     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-08-28     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e336-45     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Iron-Deficiency / physiopathology*
Attention / physiology*
Cross-Sectional Studies
Evoked Potentials, Visual / physiology*
Memory / physiology
Photic Stimulation / methods
Recognition (Psychology) / physiology*
Grant Support
P01 HD039386/HD/NICHD NIH HHS; P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-01A10001/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-020001/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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